Rumble young man, Rumble... He got the Parkinson's disease

I love to see my name where everyone can read it.

someday Im gonna see it in bright, bright light. (Muhammad Ali)

He was the legend. He was born as Muhammad Ali. Yeah he was the generation of the world best boxer. So what was so special about him that I want to talk about? Oh he had the Parkinson's disease. Trust me, Dr Adibah said so. Hahah >.<

Parkinson Disease

-Defined as a syndrome consisting of variable combination of tremor, rigidity, bradykinesia and characteristic disturbance of gait and posture.

-Causes are unclear but there are number of factors; toxins, free radical, aging, and genetic is possible but no single gene is identified. Basically it is idiopathic, unknown causes.

-Pathogenesis:

1. loss of dopaminergic cells in the substantia nigra. Relative deficiency of dopamine. Imbalance between Dopamine  and Ach. Ach is no longer inhibited by dopamine- relative excess of dopamine.

2.This results in abnormal activity in the putamen, causing the primary features of the disease.

3.When substiantia nigra projection to putamen is impaired, the globus pallidus interna and subthalamic nucleus begin to function abnormally.

4. The result is that the brain is no longer able to sufficiently control motor function.

- Symptoms

Motor features;

1. Pill rolling tremor in hand. Also can occur with the mouth and chin. Resting tremor.

2. Bradyknesia

3.Cogwheel rigidity.

4. Postural instability and festinant gait

Non motor features;

1. Depression and anxiety

2. cognitive disorder- dimentia

3. Sleep abnormalities- REM sleep behaviour disorder

4. Autonomic disfunction- Constipation and Orthostatic hypotension

5. Olfactory dysfunction

6. Fatigue and weight loss

-Treatment and therapies

1.Combination of levodopa and carbidopa( peripheral decarboxylase inhibitor)

2.Dopamine receptor agonist; bromocriptin, pergolide, pramipexole, ropinirole, cabergoline.

3. Amantadine

4. Anticholinergic

5. Deep brain stimulation

6. Makan kacang parang @ fava bean .. cos contain levodopa

..........................................................................................................................................................

Haha.. Got a lot of medical jargons right? Absolutely non medical personel wont understand what I wrote about.. hEE~ ampun! I just copy from my lecture notes. Just to help me memorise all those facts.

p/s : Wondering, do i manage to live up to my old age, having this disease, or any other elderly disease, or maybe I wont get all those disease beacause I did not even reach my oldies time. Hmm... what is ahead is not in my diary, not even in my head. DariNya kita datang, kepadaNya jua kita kembali.